Book Summary — Lifespan: Why We Age But Don’t Have To [David Sinclair].

Fynn Comerford
3 min readApr 23, 2023

Lifespan — Why We Age But Don’t Have To

The book is about longevity and science, exploring the underlying causes of aging and how they can be treated. In this book summary, I (very briefly) run through some of the key points covered in the book.

Ageing has a specific pathology — it can be treated

Ageing is not just a natural part of life. It has a specific pathology that can be treated. It is an underlying factor behind all diseases. This means that if we can figure out how to treat ageing, we could potentially prevent or treat a broad range of diseases.

Goal should be to increase healthspan, not lifespan

The goal of longevity research should be to increase healthspan, not just lifespan. In other words, we should focus on extending the period of life when people are healthy and active, rather than simply extending life.

Humans may possibly live past 150 years

It’s possible that humans may be able to live past 150 years. There is evidence that some animals have been able to live longer than this, and there are people alive today who have already lived past 110. It’s unclear whether humans will be able to live much longer than this, but it’s an intriguing possibility.

There are longevity genes

There are specific genes that are associated with longevity, including sirtuins, mToR, and AMPK. These genes play a role in regulating metabolism, cell growth, and the aging process.

There are 2 types of biological information we use

There are two types of biological information that we use: DNA (digital) and epigenome (analog). The epigenome is a layer of chemical modifications that sits on top of the DNA and helps to regulate gene expression. Over time, the epigenome can become damaged, which can contribute to the aging process.

The 9 hallmarks of ageing

There are nine hallmarks of aging, including genomic instability, telomere shortening, epigenetic changes, mitochondrial dysfunction, altered intercellular communication, inflammation, and loss of proteostasis. Each of these hallmarks plays a…



Fynn Comerford

CoS at Lorentz Bio | Frequency Bio Fellow | Neuroscience at The University of Edinburgh | Founder of edventure | iGEM 2020 | Videographer